Open AccessEVALUATION OF SOME HIGH RISK BACTERIAL SPECIES IN THE ORAL MICROBIOME OF HNSCC PATIENTS
Author(s) -
Valentina Stratan,
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Ţuţuianu Valeri,
Victor Sîtnic,
Cristina Popa,
Adrian Clipca,
Anastasia Monastirscaia,
Diana Cebotari,
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AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
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Publication year - 2021
Publication title -
international journal of advanced research
Language(s) - English
Resource type - Journals
ISSN - 2320-5407
DOI - 10.21474/ijar01/13891
Subject(s) - treponema denticola , fusobacterium nucleatum , aggregatibacter actinomycetemcomitans , tannerella forsythia , microbiome , head and neck squamous cell carcinoma , fusobacteria , oral microbiome , saliva , medicine , microbiology and biotechnology , pathological , actinomyces , periodontitis , biology , pathology , porphyromonas gingivalis , cancer , bacteria , bioinformatics , head and neck cancer , 16s ribosomal rna , genetics , honeysuckle , bacteroidetes , alternative medicine , traditional chinese medicine
In this study we evaluated the composition of seven high risk periodontitis species of microorganisms in the oral microbiome of patients with different forms of head and neck squamous cell carcinoma (HNSCC). The laboratory analyses were performed using the method of quantitative real-time amplification (qPCR) of 26 saliva and mouth swab samples collected from HNSCC patients. Laboratory data regarding the normal or pathological presence of studied species were integrated with patients clinical conditions and some lifestyle factors. The results show that the highest frequency of pathological concentration is in the case of Fusobacterium nucleatum and Tannerella forsythia, while the lowest frequency is observed for microorganisms Aggregatibacter actinomycetemcomitans and Treponema denticola.