Open AccessINVASIVE FUNGAL INFECTIONS IN COVID-19 PATIENTS IN THE INTENSIVE CARE UNIT: ABOUT 5 CASES
Author(s) -
Loubna Darfaoui,
Jihane Oussaga,
Ayoub Belhaj,
El Aissaoui Youness,
Mohamed Esbaai,
El Mostafa El Mezouari,
R. Moutaj
Publication year - 2021
Publication title -
international journal of advanced research
Language(s) - English
Resource type - Journals
ISSN - 2320-5407
DOI - 10.21474/ijar01/13660
Subject(s) - intensive care unit , aspergillosis , medicine , bronchoalveolar lavage , superinfection , pneumonia , intensive care medicine , candida albicans , sepsis , mortality rate , retrospective cohort study , ards , lung , immunology , biology , virus , microbiology and biotechnology
Covid-19 is a serious pathology it is associated with a deep immunodepression which favors invasive fungal infections especially in patients in intensive care unit. We report in our work a series of five covid-19 patients with fungal co-infection. We conducted a retrospective study including all COVID-19 patients hospitalized in intensive care unit for acute respiratory distress syndrome. Patients who presented a clinical worsening during their hospitalization were sampled with mycological study (bronchoalveolar lavage, serum and fungal blood culture). The diagnosis of fungal superinfection was retained in five patients, two of whom had probable invasive pulmonary aspergillosis. Two other patients had a Cryptoccocusneoformans infection, one of which was disseminated. Candida albicans sepsis was found in only one patient. In the literature, invasive candidiasis and invasive pulmonary aspergillosis. in covid-19 patients are associated with a high morbidity and mortality rate, hence the importance of early diagnosis and management. It should be noted that the clinical presentation of invasive fungal infections is not very specific, especially at the beginning of the infection when antifungal treatment is more effective.