Open AccessEVALUATION OF BIOCHEMICAL AND OXIDATIVE STRESS MARKERS AS PREDICTIVE TOOL FOR DIAGNOSIS OF BIRTH ASPHYXIA AND ENCEPHALOPATHY IN NEW BORN
Author(s) -
Shweta Singh,
Babita Singhal,
Bhumika Upadhyay,
Chandra M. Kumar
Publication year - 2021
Publication title -
international journal of advanced research
Language(s) - English
Resource type - Journals
ISSN - 2320-5407
DOI - 10.21474/ijar01/13624
Subject(s) - asphyxia , medicine , apgar score , malondialdehyde , encephalopathy , umbilical cord , neonatal encephalopathy , oxidative stress , brain damage , superoxide dismutase , cord blood , perinatal asphyxia , creatine kinase , gastroenterology , lactate dehydrogenase , population , anesthesia , fetus , pregnancy , biology , immunology , biochemistry , genetics , enzyme , environmental health
Background:Birth asphyxia and resultanthypoxic ischemic encephalopathy (HIE), are leading cause of mortality and morbidity in newborns. Delayed diagnosis may lead to progression of HIE as its clinical features may not be evident at birth as they evolve with time. This study was done to identify asphyxia and HIE in term neonates by evaluating biochemical and oxidative stress markers in umbilical cord blood sample taken immediately after delivery. Methodology: This prospective cross sectional study was done on term neonates in a tertiary care hospital (n=60)Thestudy population was then divided into two equal groups on the basis of Apgar score at 1 minute, with score 7 (n=26) was not statistically significant at 95% CI. Conclusion: This study helps in diagnosis of neonatal asphyxia at an early stage thereby preserving the normal functioning of neonatal brain so that the brain functioning is not compromised.