Open AccessGALECTIN-3 IN MODULATING INFLAMMATION IN ADIPOCYTES AND MACROPHAGES
Author(s) -
Braja Kishori Panigrahi,
Swati Das,
Faina Philberta Dumpala,
Reshma Vagicharla,
Sai Kumar Kunderu,
Vijaya Lakshmi Bodiga
Publication year - 2020
Publication title -
international journal of advanced research
Language(s) - English
Resource type - Journals
ISSN - 2320-5407
DOI - 10.21474/ijar01/12008
Subject(s) - galectin , galectin 1 , inflammation , galectin 3 , pathogenesis , immune system , endogeny , immunology , medicine , biology
Previous studies on endogenous galectin-3 proved its role in the pathogenesis of asthma, heart attack and obesity. Galectin-3 applied therapeutically as gene therapy suppresses the inflammatory response in a rat asthma model thus presenting novel therapeutic approach to the treatment of several diseases. Despite availability of enormous data concerning galectin-3 expression, the mechanisms of regulation of galectin-3 expression are relatively poorly defined. Galectins are either pro-inflammatory or anti-inflammatory, such as galectin-1, may be employed as anti-inflammatory agents, while others, such as galectin-3, are evidently suitable targets for anti-inflammatory drugs. Investigating galectin-3 in the immune response has demonstrated that this protein displays pro- and anti-inflammatory roles depending on the target cell type, whether galectin-3 is acting exogenously or endogenously, its expression level and other inflammatory factors. It is therefore imperative that all these factors be taken into consideration should galectin-3 be used therapeutically.