Open AccessFORMULATION AND EVALUATION OF ANTIFUNGAL TOPICAL GEL OF C. TORA SEED EXTRACT
Author(s) -
Sanjay Krishna Pandey,
Jai Narayan Mishra,
Dhaneshwar K. Vishwakarma
Publication year - 2020
Publication title -
international journal of advanced research
Language(s) - English
Resource type - Journals
ISSN - 2320-5407
DOI - 10.21474/ijar01/11796
Subject(s) - antifungal , candida albicans , chromatography , chemistry , irritation , viscosity , materials science , microbiology and biotechnology , medicine , biology , composite material , immunology
Purpose: To formulate novel topical antifungal gel containing seed extract of c.tora. and to evaluate their antifungal potential. Method: the gel was formulated by a cold mechanical method. Prepared gel was subjected to various evaluation parameters like ph, viscosity, spread ability, homogeneity and antifungal activity. Results: Prepared topical gel of extract was pH range of 6.25±0.05 to 6.45±0.15, viscosity range 386±27.90 to 680±45.50cp, spread ability 40±2.5 to 38±2 mm and homogenous. Prepared topical gel was shown zone of inhibition ranges from 13.5±0.5 to 23.5±0.5 mm for candida albicans. Conclusion: Formulation F6 was shown better antifungal activity as compared to its other formulations. The prepared gel formulation was found useful for topical application due to its neutral pH, good spread ability, low viscosity and no irritation on human skin.