Open AccessBioprosthetic Aortic Valve Degeneration: a Review from a Basic Science Perspective
Author(s) -
Tiago Velho,
Rafael Maniés Pereira,
Frederico Leon Arrabal Fernandes,
Nuno Guerra,
Ricardo Ferreira,
Ângelo Nobre
Publication year - 2022
Publication title -
brazilian journal of cardiovascular surgery
Language(s) - English
Resource type - Journals
eISSN - 1678-9741
pISSN - 0102-7638
DOI - 10.21470/1678-9741-2020-0635
Subject(s) - medicine , degeneration (medical) , aortic valve , stenosis , cardiology , aortic valve stenosis , heart valve , surgery , pathology
The increase in the prevalence of aortic stenosis due to an aging population has led to an increasing number of surgical aortic valve replacements. Over the past 20 years, there has been a major shift in preference from mechanical to bioprosthetic valves. However, despite efforts, there is still no "ideal" bioprosthesis. It is crucial to understand the structure, biology, and function of native heart valves to design more intelligent, strong, durable, and physiological heart valve tissues.