Open AccessPreoperative Neutrophil-Lymphocyte Ratio Can Predict Outcomes for Patients Undergoing Tetralogy of Fallot Repair
Author(s) -
Valdano Manuel,
Leonardo Augusto Miana,
Gustavo Pampolha Guerreiro,
Aída Luiza Ribeiro Turquetto,
Rômullo Medeiros Santos,
Natália Fernandes,
Davi Freitas Tenório,
Luiz Fernando Canêo,
Fábio Biscegli Jatene,
Marcelo Biscegli Jatene
Publication year - 2021
Publication title -
brazilian journal of cardiovascular surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.324
H-Index - 26
eISSN - 1678-9741
pISSN - 0102-7638
DOI - 10.21470/1678-9741-2020-0408
Subject(s) - medicine , tetralogy of fallot , confidence interval , neutrophil to lymphocyte ratio , receiver operating characteristic , intensive care unit , area under the curve , preoperative care , surgery , cardiology , heart disease , lymphocyte
Elevated neutrophil-lymphocyte ratio (NLR) has been associated with poorer outcomes in cyanotic patients undergoing single ventricle palliation. Little is known about this biomarker on patients with tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease. Our objective is to study the impact of preoperative NLR on outcomes of TOF patients undergoing total repair. Methods This retrospective study included 116 consecutive patients between January 2014 and December 2018. Preoperative NLR was measured from the last complete blood count test before the surgery. Using the cutoff value of 0.80, according to the receiver-operating characteristic (ROC) curve, the sample was divided into two groups (NLR < 0.80 and ≥ 0.80). The primary endpoint was hospital length of stay (LOS). Results ROC curves showed that higher preoperative NLR was associated with longer hospital LOS, with an area under the curve of 0.801±0.040 (95% confidence interval 0.722 - 0.879; P<0.001). High preoperative NLR was also associated with long intensive care unit (ICU) LOS (P=0.035). Preoperative NLR predicted longer hospital LOS with a sensitivity of 63% and a specificity of 81.4%. Conclusion Higher preoperative NLR was associated with long ICU and hospital LOS in patients undergoing TOF repair.