Open Access<p>Characterization and Immunomodulation of Canine Amniotic Membrane Stem Cells</p>
Author(s) -
Alessandra de Oliveira Pinheiro,
Valéria Maria Lara,
Aline Fernanda de Souza,
Juliana Barbosa Casals,
Fabiana Fernandes Bressan,
Paulo Fantinato Neto,
Vanessa Cristina de Oliveira,
Daniel Lahan Martins,
Carlos Eduardo Ambrósio
Publication year - 2020
Publication title -
stem cells and cloning
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 22
ISSN - 1178-6957
DOI - 10.2147/sccaa.s237686
Subject(s) - cd90 , biology , mesenchymal stem cell , stem cell , microbiology and biotechnology , andrology , immunology , cd34 , immunophenotyping , flow cytometry , medicine
Amniotic membrane stem cells have a high capacity of proliferation, cell expansion, and plasticity, as well as immunomodulatory properties that contribute to maternal-fetal tolerance. Owing to the lack of research on human amniotic membrane at different gestational stages, the canine model is considered ideal because of its genetic and physiological similarities. We aimed to characterize the canine amniotic membrane (CAM) cell lineage in different gestational stages and evaluate the expression of immunomodulatory genes.