Open AccessAssociation of Hair Concentrations of Antiretrovirals with Virologic Outcomes Among People Living with HIV in Guangxi, China
Author(s) -
Quan Zhang,
Xiaoming Li,
Shan Qiao,
Shuaifeng Liu,
Zhiyong Shen,
Yuejiao Zhou
Publication year - 2021
Publication title -
patient preference and adherence
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.885
H-Index - 48
ISSN - 1177-889X
DOI - 10.2147/ppa.s277965
Subject(s) - lamivudine , efavirenz , medicine , zidovudine , odds ratio , logistic regression , multivariate analysis , viral load , human immunodeficiency virus (hiv) , antiretroviral treatment , cross sectional study , virology , antiretroviral therapy , viral disease , virus , pathology , chronic hepatitis
Background Hair concentrations of antiretrovirals are an innovative and non-invasive method for measuring cumulative antiretroviral exposure and assessing long-term antiretroviral adherence. This study aimed to examine hair concentrations of antiretrovirals in relation to virologic outcomes among PLHIV in Guangxi, China. Methods Cross-sectional data of hair concentrations of antiretrovirals and HIV viral load were collected from 215 PLHIV in Guangxi, China. Multivariate logistic regression analyses were used to examine the association of hair concentrations of antiretrovirals with virologic outcomes. Results Of the 215 participants, 215, 67, and 163 PLHIV are receiving lamivudine, zidovudine, and efavirenz, respectively. Multivariate analysis revealed that hair concentrations of lamivudine [odds ratio = 16.52, 95% CI 2.51–108.60, p = 0.004] and efavirenz [odds ratio = 14.26, 95% CI 1.18–172.01, p = 0.036], but not zidovudine [odds ratio = 1.77, 95% CI 0.06–56.14, p = 0.747], were the strongest independent predictor of virologic suppression when controlling for sociodemographic and other HIV-related characteristics. Conclusion Hair concentrations of lamivudine and efavirenz were the strongest independent predictor of virologic suppression among Chinese PLHIV. Hair analysis of antiretrovirals may provide a non-invasive, cost-effective tool that predicts virologic suppression among PLHIV in China.