Open AccessSignificant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)
Author(s) -
F. Geurs
Publication year - 2011
Publication title -
pragmatic and observational research
Language(s) - English
Resource type - Journals
ISSN - 1179-7266
DOI - 10.2147/por.s15391
Subject(s) - zoledronic acid , medicine , n terminal telopeptide , bone resorption , refractory (planetary science) , pain relief , analgesic , urology , surgery , anesthesia , osteocalcin , chemistry , biochemistry , alkaline phosphatase , physics , astrobiology , enzyme
In symptomatic bone metastases with significant pain, refractory to standard analgesics and radiotherapy, loading dose zoledronic acid (ZA) represents a simple and nontoxic treatment to obtain significant pain relief in a very short time. Its analgesic effect is limited to patients with massive osteoclast activation with high initial serum C-telopeptide (CTX). The pain reduction is proportionally correlated with the reduction of CTX.