Open AccessBone Marrow Mesenchymal Stem Cells-Derived Exosomal miR-425-5p Inhibits Acute Myeloid Leukemia Cell Proliferation, Apoptosis, Invasion and Migration by Targeting WTAP
Author(s) -
Ling Zhang,
Bijay Khadka,
Jieying Wu,
Yashu Feng,
Bing Liang,
Ran Xiao,
Jiajun Liu
Publication year - 2021
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s286326
Subject(s) - mesenchymal stem cell , cd90 , cd44 , cancer research , microvesicles , exosome , myeloid leukemia , bone marrow , flow cytometry , cd34 , microrna , stem cell , medicine , immunology , biology , cell , pathology , microbiology and biotechnology , biochemistry , genetics , gene
Acute myeloid leukemia (AML) is a predominant blood malignancy with high mortality and severe morbidity. AML is affected by microRNAs (miRNAs) loaded in exosomes derived from bone marrow mesenchymal stem cells (BM-MSCs). MiR-425-5p has been reported to participate in different cancer models. However, the function of BM-MSCs-derived exosomal miR-425-5p in AML is unclear.