Bone Marrow Mesenchymal Stem Cells-Derived Exosomal miR-425-5p Inhibits Acute Myeloid Leukemia Cell Proliferation, Apoptosis, Invasion and Migration by Targeting WTAP | Zendy

Ling Zhang | Zendy; Bijay Khadka | Zendy; Jieying Wu | Zendy; Yashu Feng | Zendy; Bing Long | Zendy; Ruozhi Xiao | Zendy; Jiajun Liu | Zendy

Open Access

Bone Marrow Mesenchymal Stem Cells-Derived Exosomal miR-425-5p Inhibits Acute Myeloid Leukemia Cell Proliferation, Apoptosis, Invasion and Migration by Targeting WTAP

Author(s) -

Ling Zhang,

Bijay Khadka,

Jieying Wu,

Yashu Feng,

Bing Long,

Ruozhi Xiao,

Jiajun Liu

Publication year - 2021

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s286326

Subject(s) - mesenchymal stem cell , cd90 , microvesicles , exosome , cd44 , myeloid leukemia , cancer research , bone marrow , flow cytometry , cd34 , microrna , stem cell , medicine , immunology , biology , cell , pathology , microbiology and biotechnology , genetics , gene , biochemistry

Acute myeloid leukemia (AML) is a predominant blood malignancy with high mortality and severe morbidity. AML is affected by microRNAs (miRNAs) loaded in exosomes derived from bone marrow mesenchymal stem cells (BM-MSCs). MiR-425-5p has been reported to participate in different cancer models. However, the function of BM-MSCs-derived exosomal miR-425-5p in AML is unclear.

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