Open Access<p>CCNB1 Expedites the Progression of Cervical Squamous Cell Carcinoma via the Regulation by FOXM1</p>
Author(s) -
Shufeng Li,
Ning Liu,
Jinxia Piao,
Fanxu Meng,
Yanyan Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s279951
Subject(s) - foxm1 , cell cycle , cancer research , gene knockdown , cell growth , biology , cell cycle checkpoint , carcinogenesis , apoptosis , cancer , genetics
Cervical squamous cell carcinoma (CSCC) is responsible for 80-85% of cervical cancer. Cyclin B1 (CCNB1) represents a hub gene during the development of cervical cancer. However, the oncogenic role of CCNB1 in CSCC remains unclear. Our study aims to explore the mechanism underlying CCNB1 regulation on cell cycle progression in CSCC cells.