Long Intergenic Non-Protein Coding RNA 519 Promotes the Biological Activities of Tongue Squamous Cell Carcinoma by Sponging microRNA-876-3p and Consequently Upregulating MACC1 | Zendy

Dejun Liu | Zendy; Jing Zhao | Zendy; Huiling Wang | Zendy; Hui Li | Zendy; Yanjie Li | Zendy; Wangsen Qin | Zendy

Open Access

<p>Long Intergenic Non-Protein Coding RNA 519 Promotes the Biological Activities of Tongue Squamous Cell Carcinoma by Sponging microRNA-876-3p and Consequently Upregulating MACC1</p>

Author(s) -

Dejun Liu,

Jing Zhao,

Huiling Wang,

Hui Li,

Yanjie Li,

Wangsen Qin

Publication year - 2020

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s279798

Subject(s) - cell growth , cancer research , microrna , downregulation and upregulation , competing endogenous rna , cell culture , cell , biology , cell migration , apoptosis , long non coding rna , in vivo , microbiology and biotechnology , chemistry , gene , biochemistry , genetics

Long intergenic non-protein coding RNA 519 ( LINC00519 ) promotes the development of lung squamous cell carcinoma. In this study, we detected the expression of LINC00519 in tongue squamous cell carcinoma (TSCC) and examined its clinical significance. Additionally, the regulatory effects of LINC00519 on behaviors of TSCC tumor cells were explored through functional experiments. Finally, mechanistic studies were performed to elucidate the molecular events underlying the tumor-promoting actions of LINC00519 in TSCC.

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