Open Access<p>Long Non-Coding RNA LINC00239 Functions as a Competitive Endogenous RNA by Sponging microRNA-484 and Enhancing KLF12 Expression to Promote the Oncogenicity of Colorectal Cancer</p>
Author(s) -
Xiaofan Luo,
Meng Yue,
Chenguang Li,
Di Sun,
Lei Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s278582
Subject(s) - competing endogenous rna , gene knockdown , microrna , cancer research , cell growth , long non coding rna , rna , downregulation and upregulation , biology , colorectal cancer , cell , flow cytometry , apoptosis , cancer , microbiology and biotechnology , gene , genetics
Long intergenic non-protein coding RNA 239 ( LINC00239 ) is an oncogenic long non-coding RNA in acute myeloid leukemia. We aimed to determine LINC00239 expression in colorectal cancer (CRC) and examine the influences of LINC00239 on tumor behaviors of CRC cells. Furthermore, the mechanism underlying the actions of LINC00239 in CRC was unveiled in detail.