Open Access<p>Long Noncoding RNA LINC00525 Promotes the Aggressive Phenotype of Chordoma Through Acting as a microRNA-505-3p Sponge and Consequently Raising HMGB1 Expression</p>
Author(s) -
Lei Li,
Guohua Lv,
Bing Wang,
Hong Ma
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s268678
Subject(s) - chordoma , gene knockdown , gene silencing , cancer research , microrna , biology , carcinogenesis , long non coding rna , rna , non coding rna , microbiology and biotechnology , apoptosis , cancer , pathology , medicine , gene , genetics
Long intergenic non-protein coding RNA 525 (LINC00525), a long noncoding RNA, has been implicated in the carcinogenesis and progression of many human cancer types. However, the detailed roles of LINC00525 in chordoma and the underlying mechanisms are not fully understood. Here, we aimed to determine whether LINC00525 could modulate the oncogenicity of chordoma cells and to elucidate in detail the molecular events underlying these tumor-promoting activities.