Open Access<p>Targeting of KDM5A by miR-421 in Human Ovarian Cancer Suppresses the Progression of Ovarian Cancer Cells</p>
Author(s) -
Fang Ren,
Christina Shrestha,
Huirong Shi,
Fangfang Sun,
Minghui Zhang,
Yuan Cao,
Gailing Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s266211
Subject(s) - ovarian cancer , cancer research , gene silencing , biology , microrna , cell growth , tissue microarray , transfection , cancer , cell culture , gene , genetics
The retinoblastoma binding protein RBP2 (KDM5A) is a histone demethylase that promotes cell growth in many human cancers. A series of functional experiments were conducted to explore the role of miR-421/KDM5A in ovarian cancer cells and their underlying molecular mechanisms.