Open Access<p>Down-Regulation of SREBP via PI3K/AKT/mTOR Pathway Inhibits the Proliferation and Invasion of Non-Small-Cell Lung Cancer Cells</p>
Author(s) -
Bo Zhang,
Jianchun Wu,
Peng Guo,
Yi Wang,
Zhihong Fang,
Jie Tian,
Yongchun Yu,
Wenjing Teng,
Yingbin Luo,
Yan Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s266073
Subject(s) - pi3k/akt/mtor pathway , protein kinase b , downregulation and upregulation , cancer research , cell growth , chemistry , lung cancer , microbiology and biotechnology , biology , signal transduction , medicine , biochemistry , gene
Lung cancer is one of the most common causes of cancer-related deaths worldwide, metabolic disorders are also a problem that puzzles mankind. SREBP is overexpressed in non-small-cell lung cancer (NSCLC) and is also a key regulator of lipid synthesis. However, the mechanisms by which SREBP regulates the proliferation, migration and invasion in NSCLC remain unclear.