Open Access<p>Implications of the Receptor Tyrosine Kinase Axl in Gastric Cancer Progression</p>
Author(s) -
L. He,
Yunpeng Liu,
Jixin Hou,
Jingshen Wu,
Guorong Lv
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s257606
Subject(s) - gas6 , cancer research , axl receptor tyrosine kinase , cell growth , metastasis , receptor tyrosine kinase , cancer , downregulation and upregulation , ectopic expression , carcinogenesis , biology , chemistry , medicine , cell culture , signal transduction , microbiology and biotechnology , jak stat signaling pathway , biochemistry , genetics , gene
Gastric cancer (GC) is an aggressive malignancy with high lethality. Systematic chemotherapy is the main therapeutic strategy for advanced GC patients. The overexpression of Axl is associated with poor prognosis and regulates tumor growth and metastasis in many types of cancer. However, the role of Axl in GC progression remains elusive.