Open Access<p>Coronin 3 Promotes the Development of Oncogenic Properties in Glioma Through the Wnt/β-Catenin Signaling Pathway</p>
Author(s) -
Min Wang,
Qi Li,
Shengyuan Yu,
Zexiang Zhang,
Ping Qiu,
Yubao Zhang,
Wei Yang,
Guofeng Xu,
Tong-jiang Xu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s257001
Subject(s) - wnt signaling pathway , gene knockdown , glioma , cyclin d1 , cancer research , carcinogenesis , biology , small hairpin rna , catenin , downregulation and upregulation , cell growth , signal transduction , microbiology and biotechnology , cell culture , cell cycle , cell , cancer , gene , genetics
Evidence indicates that the actin-binding protein Coronin 3, which is aberrantly expressed in various cancers, is associated with cancer development and progression. However, little is known about the role of Coronin 3 in glioma tumorigenesis. Here, we aimed to explore the biological function and regulatory mechanism of Coronin 3 in glioblastoma (GBM).