Open Access<p>lncRNA LSINCT5 Regulates miR-20a-5p/XIAP to Inhibit the Growth and Metastasis of Osteosarcoma Cells</p>
Author(s) -
Shijie Liao,
Jian Guan,
Hao Yuan Mo,
Juan He,
Xinli Zhan
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s251843
Subject(s) - xiap , osteosarcoma , microrna , cancer research , metastasis , cell growth , oncogene , chemistry , rna , microbiology and biotechnology , biology , cell , gene , cell cycle , cancer , apoptosis , biochemistry , genetics , programmed cell death , caspase
More and more evidence has shown that non-coding RNA (ncRNA), including long ncRNA (lncRNA) and micro RNA (miRNA), plays a crucial regulatory role in osteosarcoma (OS). Previously, we revealed a Rho-related coiled coil incorporating protein kinase 1(XIAP). A transfer-related gene is negatively regulated by microRNA-20a-5p (miR-20a-5p) and plays the role of oncogene in OS. It is not clear if any lncRNA is involved in the axial upstream of miR-20a-5p/XIAP.