Open Access<p>Dihydroartemisinin Prevents Progression and Metastasis of Head and Neck Squamous Cell Carcinoma by Inhibiting Polarization of Macrophages in Tumor Microenvironment</p>
Author(s) -
Ran Chen,
Xin Lu,
Zhen Li,
Yajing Sun,
Zhengxin He,
Xiaoming Li
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s249046
Subject(s) - head and neck squamous cell carcinoma , cancer research , macrophage polarization , m2 macrophage , tumor microenvironment , tumor associated macrophage , angiogenesis , metastasis , cell migration , stat3 , chemistry , tumor progression , medicine , macrophage , cell , cancer , signal transduction , head and neck cancer , biochemistry , tumor cells , in vitro
Polarized M2 macrophages are an important type of tumor-associated macrophage (TAM), with roles in the growth, invasion, and migration of cancer cells in the tumor microenvironment. Dihydroartemisinin (DHA), a traditional Chinese medicine extract, has been shown to inhibit the progression and metastasis of head and neck squamous cell carcinoma (HNSCC); however, the effect of DHA on cancer prevention, and the associated mechanism, has not been investigated in the tumor microenvironment.