Open Access<p>miR-188-5p Promotes Tumor Growth by Targeting CD2AP Through PI3K/AKT/mTOR Signaling in Children with Acute Promyelocytic Leukemia</p>
Author(s) -
Dao Wang,
Jiao Chen,
Yanjie Ding,
Huimin Kong,
Hongliang You,
Yang Zhao,
Huixia Wei,
Yufeng Liu
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s244813
Subject(s) - pi3k/akt/mtor pathway , acute promyelocytic leukemia , leukemia , cell growth , apoptosis , cancer research , clone (java method) , pten , biology , protein kinase b , downregulation and upregulation , flow cytometry , medicine , cell culture , microbiology and biotechnology , immunology , gene , genetics , retinoic acid
Pediatric acute promyelocytic leukemia (APL) accounts for 10% of pediatric acute myelogenous leukemia (AML) case and is accompanied by a tendency to hemorrhage. miR-188-5p plays an important role in adult AML. Therefore, the purpose of this study was to explore the effects of miR-188-5p on cell proliferation and apoptosis and tumor growth, and its mechanism in pediatric APL patients.