miR-188-5p Promotes Tumor Growth by Targeting CD2AP Through PI3K/AKT/mTOR Signaling in Children with Acute Promyelocytic Leukemia | Zendy

Dao Wang | Zendy; Jiao Chen | Zendy; Yanjie Ding | Zendy; Huimin Kong | Zendy; Hongliang You | Zendy; Yan-Ting Zhao | Zendy; Huixia Wei | Zendy; Yufeng Liu | Zendy

Open Access

<p>miR-188-5p Promotes Tumor Growth by Targeting CD2AP Through PI3K/AKT/mTOR Signaling in Children with Acute Promyelocytic Leukemia</p>

Author(s) -

Dao Wang,

Jiao Chen,

Yanjie Ding,

Huimin Kong,

Hongliang You,

Yan-Ting Zhao,

Huixia Wei,

Yufeng Liu

Publication year - 2020

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s244813

Subject(s) - pi3k/akt/mtor pathway , leukemia , cell growth , acute promyelocytic leukemia , cancer research , pten , apoptosis , clone (java method) , protein kinase b , downregulation and upregulation , flow cytometry , biology , medicine , cell culture , microbiology and biotechnology , immunology , gene , genetics , retinoic acid

Pediatric acute promyelocytic leukemia (APL) accounts for 10% of pediatric acute myelogenous leukemia (AML) case and is accompanied by a tendency to hemorrhage. miR-188-5p plays an important role in adult AML. Therefore, the purpose of this study was to explore the effects of miR-188-5p on cell proliferation and apoptosis and tumor growth, and its mechanism in pediatric APL patients.

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