Open Access<p>CCDC7 Activates Interleukin-6 and Vascular Endothelial Growth Factor to Promote Proliferation via the JAK-STAT3 Pathway in Cervical Cancer Cells</p>
Author(s) -
Cong Zhou,
Xiang He,
Qi Zeng,
Peng Zhang,
Chunting Wang
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s244663
Subject(s) - gene knockdown , vascular endothelial growth factor , cancer research , cell growth , medicine , immunohistochemistry , cancer , western blot , cervical cancer , vascular endothelial growth factor a , pathology , biology , cell culture , vegf receptors , gene , biochemistry , genetics
Tumor growth is one of the most lethal attributes of human malignancy. The expression of CCDC7, a novel gene which has multiple functions, has been shown to be associated with tumor growth and poor prognosis in patients with cancer. However, the specific functions of CCDC7 remain unclear. Here, we investigated the molecular mechanisms underlying the effects of CCDC7 on proliferation in cervical cancer.