Open Access<p>Long Non-Coding RNA DLEU1 Up-Regulates BIRC6 Expression by Competitively Sponging miR-381-3p to Promote Cisplatin Resistance in Nasopharyngeal Carcinoma</p>
Author(s) -
Hangbo Li,
Jia Huang,
Sa Yu,
Zhiping Lou
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s237456
Subject(s) - competing endogenous rna , nasopharyngeal carcinoma , cancer research , long non coding rna , malat1 , microarray analysis techniques , oncogene , cisplatin , biology , microrna , luciferase , carcinogenesis , in vivo , in vitro , microbiology and biotechnology , cell culture , medicine , downregulation and upregulation , gene expression , cell , transfection , gene , chemotherapy , genetics , cell cycle , radiation therapy
Cisplatin (DDP) resistance has become an obstacle to chemotherapy for nasopharyngeal carcinoma (NPC) patients. Recent evidences indicate that long noncoding RNAs (lncRNAs) are involved in tumorigenesis and chemoresistance. However, the potential role of lncRNAs in NPC progression remains largely unknown.