Open Access<p>LncRNA LINC01140 Inhibits Glioma Cell Migration and Invasion via Modulation of miR-199a-3p/ZHX1 Axis</p>
Author(s) -
Yanchao Xin,
Wuzhong Zhang,
Chongchong Mao,
Jianxin Li,
Xianzhi Liu,
Junbo Zhao,
Junfeng Xue,
Junqing Li,
Yonglu Ren
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s230895
Subject(s) - glioma , gene silencing , cancer research , blot , in vivo , cell migration , malignancy , cell , microrna , cell growth , medicine , biology , pathology , gene , genetics
Glioma is an aggressive tumor from the nervous system, which causes more than 70% of primary malignant brain tumors. Considering its severe malignancy, there is an urgent need to investigate more practical markers to understand the pathogenesis of glioma, and potential treatment methods for glioma patients. In the paper, we are focused on examining the roles of LINC01140, miR-199a-3p, and ZHX1 in the progression of gliomas, as well as their inner associations and modulation mechanisms.