Open Access<p>MicroRNA-769-5p Inhibits Pancreatic Ductal Adenocarcinoma Progression by Directly Targeting and Downregulating ETS Proto-Oncogene 1</p>
Author(s) -
Kai Chen,
Feng Lan,
Shanshan Yu,
Chang-Hong Yu,
Nannan Chi
Publication year - 2020
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s218876
Subject(s) - pancreatic ductal adenocarcinoma , microrna , oncogene , cancer research , medicine , oncology , bioinformatics , biology , pancreatic cancer , cancer , gene , genetics , cell cycle
MicroRNA-769-5p (miR-769) is aberrantly expressed and plays crucial roles in non-small cell lung cancer and melanoma. However, the expression pattern, biological role, and mechanisms of action of miR-769 in pancreatic ductal adenocarcinoma (PDAC) are yet to be fully elucidated. Therefore, we attempted to determine the potential regulatory function of miR-769 in PDAC progression and to explore the underlying mechanisms in detail.