Long Non-Coding RNA EGOT Promotes the Malignant Phenotypes of Hepatocellular Carcinoma Cells and Increases the Expression of HMGA2 via Down-Regulating miR-33a-5p | Zendy

Shi-Min Wu | Zendy; Hongwu Ai | Zendy; Kehui Zhang | Zendy; Yun Hao | Zendy; Fei Xie | Zendy

Open Access

<p>Long Non-Coding RNA EGOT Promotes the Malignant Phenotypes of Hepatocellular Carcinoma Cells and Increases the Expression of HMGA2 via Down-Regulating miR-33a-5p</p>

Author(s) -

Shi-Min Wu,

Hongwu Ai,

Kehui Zhang,

Yun Hao,

Fei Xie

Publication year - 2019

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s218308

Subject(s) - hepatocellular carcinoma , western blot , flow cytometry , long non coding rna , biology , viability assay , real time polymerase chain reaction , rna , cancer research , microbiology and biotechnology , apoptosis , gene , genetics

Chronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). EGOT is a long non-coding RNA (lncRNA) induced after HCV infection that increases viral replication by antagonizing the antiviral response. Interestingly, EGOT also acts as a crucial regulator in multiple cancers. However, its role in HCC remains unclear.

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