Open Access<p>Long Non-Coding RNA EGOT Promotes the Malignant Phenotypes of Hepatocellular Carcinoma Cells and Increases the Expression of HMGA2 via Down-Regulating miR-33a-5p</p>
Author(s) -
Shimin Wu,
Hongwu Ai,
Kehui Zhang,
Yun Huang,
Fei Xie
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s218308
Subject(s) - hepatocellular carcinoma , western blot , flow cytometry , long non coding rna , biology , viability assay , real time polymerase chain reaction , rna , cancer research , microbiology and biotechnology , apoptosis , gene , genetics
Chronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). EGOT is a long non-coding RNA (lncRNA) induced after HCV infection that increases viral replication by antagonizing the antiviral response. Interestingly, EGOT also acts as a crucial regulator in multiple cancers. However, its role in HCC remains unclear.