MicroRNA-761 targets FGFR1 to suppress the malignancy of osteosarcoma by deactivating PI3K/Akt pathway | Zendy

Zhongzhe Lv | Zendy; Jinming Ma | Zendy; Jianchuan Wang | Zendy; Jianmin Lu | Zendy

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<p>MicroRNA-761 targets FGFR1 to suppress the malignancy of osteosarcoma by deactivating PI3K/Akt pathway</p>

Author(s) -

Zhongzhe Lv,

Jinming Ma,

Jianchuan Wang,

Jianmin Lu

Publication year - 2019

Publication title -

oncotargets and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.054

H-Index - 60

ISSN - 1178-6930

DOI - 10.2147/ott.s208263

Subject(s) - microrna , cancer research , gene silencing , fibroblast growth factor receptor 1 , cell growth , downregulation and upregulation , osteosarcoma , pi3k/akt/mtor pathway , apoptosis , metastasis , protein kinase b , biology , cancer , medicine , fibroblast growth factor , receptor , gene , genetics

MicroRNA-761 (miR-761) has been reported to be deregulated in many types of human cancers and play important roles in cancer genesis and progression. However, the biological roles of miR-761 in osteosarcoma (OS) and the underlying mechanisms remain largely unknown.

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