Open Access<p>MicroRNA-761 targets FGFR1 to suppress the malignancy of osteosarcoma by deactivating PI3K/Akt pathway</p>
Author(s) -
Zhongzhe Lv,
Jinming Ma,
Jianchuan Wang,
Jianrong Lu
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s208263
Subject(s) - microrna , cancer research , gene silencing , fibroblast growth factor receptor 1 , cell growth , downregulation and upregulation , pi3k/akt/mtor pathway , osteosarcoma , apoptosis , protein kinase b , metastasis , biology , cancer , medicine , fibroblast growth factor , receptor , gene , genetics
MicroRNA-761 (miR-761) has been reported to be deregulated in many types of human cancers and play important roles in cancer genesis and progression. However, the biological roles of miR-761 in osteosarcoma (OS) and the underlying mechanisms remain largely unknown.