Open Access<p>HIF1α/PD-L1 axis mediates hypoxia-induced cell apoptosis and tumor progression in follicular thyroid carcinoma</p>
Author(s) -
Lingyan Zhou,
Guofen Cha,
Liyu Chen,
Chunxu Yang,
Dong Xu,
Minghua Ge
Publication year - 2019
Publication title -
oncotargets and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.054
H-Index - 60
ISSN - 1178-6930
DOI - 10.2147/ott.s203724
Subject(s) - cancer research , apoptosis , gene knockdown , medicine , tumor hypoxia , hypoxia (environmental) , metastasis , pathology , biology , chemistry , cancer , radiation therapy , biochemistry , organic chemistry , oxygen
Hypoxia-inducible factor 1α (HIF-1α) and programmed cell death-1 protein ligand 1 (PD-L1) are implicated in the metastasis and progression processes of multiple cancers. Hypoxia selectively elevates PD-L1 expression via HIF1α activation in several solid tumors; however, the regulatory effect of HIF1α on PD-L1 in the pathogenesis of follicular thyroid cancer (FTC) remains unclear. This study aims to investigate the regulatory effect of HIF1α on PD-L1 and their potential roles in FTC pathogenesis.