Open AccessThe Antibacterial Comparison of 5% and 2.5% Povidone Iodine to 0.01% Hypochlorous Acid Using Corneoscleral Tissue as a Solid-Phase Medium
Author(s) -
Regis P. Kowalski,
Roheena Kamyar,
Michelle K. Rhee,
Alex Mammen,
Deepinder K. Dhaliwal,
Eric G. Romanowski,
Vishal Jhanji,
Andrew W. Eller
Publication year - 2021
Publication title -
clinical ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 56
eISSN - 1177-5483
pISSN - 1177-5467
DOI - 10.2147/opth.s328696
Subject(s) - antiseptic , hypochlorous acid , medicine , endophthalmitis , bacteria , streptococcus , bacterial growth , microbiology and biotechnology , surgery , chemistry , pathology , biology , biochemistry , genetics
Prophylactic topical antiseptics used to eliminate bacteria on the ocular surface prior to ocular surgery should be both effective and non-irritating. Five percent povidone iodine (PI) is an accepted antiseptic used for prophylaxis. Dilute 2.5% PI and 0.01% hypochlorous acid (HOCl) may be more patient comfortable and equally effective. PI at 5% and 2.5% were compared to HOCl against a battery of bacterial endophthalmitis isolates using corneoscleral tissue as a solid-phase medium to determine antiseptic efficacy.