Open AccessMinocycline is cytoprotective in human trabecular meshwork cells and optic nerve head astrocytes by increasing expression of XIAP, survivin, and Bcl-2
Author(s) -
Marcus Kernt,
Aljoscha S. Neubauer,
K. Eibl,
Armin Wolf,
Michael W. Ulbig,
Anselm Kampik,
Cristoph Hirneiss
Publication year - 2010
Publication title -
clinical ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 56
eISSN - 1177-5483
pISSN - 1177-5467
DOI - 10.2147/opth.s11216
Subject(s) - trabecular meshwork , minocycline , oxidative stress , survivin , xiap , viability assay , medicine , microglia , microbiology and biotechnology , pharmacology , chemistry , apoptosis , immunology , ophthalmology , biology , programmed cell death , glaucoma , inflammation , biochemistry , caspase , antibiotics
Primary open-angle glaucoma (POAG) is one of the leading causes of blindness. Activation of optic nerve head astrocytes (ONHA) and loss of trabecular meshwork cells (TMC) are pathognomonic for this neurodegenerative disease. Oxidative stress and elevated levels of transforming growth factor beta (TGFbeta) play an important role in the pathogenesis of POAG. This study investigates the possible antiapoptotic and cytoprotective effects of minocycline on TMC and ONHA under oxidative stress and increased TGFbeta levels.