Open AccessH-2g, a glucose analog of blood group H antigen, mediates monocyte recruitment in vitro and in vivo via IL-8/CXCL8
Author(s) -
Bradley J. Rabquer,
Yong Hou,
Jeffrey H. Ruth,
Wenjing Luo,
Daniel T. Eitzman,
Alisa E. Koch,
M. Asif Amin
Publication year - 2012
Publication title -
open access rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.63
H-Index - 14
ISSN - 1179-156X
DOI - 10.2147/oarrr.s36163
Subject(s) - in vivo , in vitro , monocyte , interleukin 8 , microbiology and biotechnology , chemistry , antigen , immunology , biology , inflammation , biochemistry , genetics
Monocyte (MN) recruitment is an essential inflammatory component of many autoimmune diseases, including rheumatoid arthritis (RA). In this study we investigated the ability of 2-fucosyllactose (H-2g), a glucose analog of blood group H antigen to induce MN migration in vivo and determined if H-2g-induced interleukin-8 (IL-8/CXCL8) plays a role in MN ingress in RA.