Open AccessElectroacupuncture Pretreatment Ameliorates Anesthesia and Surgery-Induced Cognitive Dysfunction via Activation of an α7-nAChR Signal in Aged Rats
Author(s) -
Zhigang Wang,
Tianlin Liu,
Chunyue Yin,
Yanan Li,
Fang Gao,
Lili Yu,
Qiujun Wang
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s322047
Subject(s) - medicine , postoperative cognitive dysfunction , electroacupuncture , microglia , anesthesia , cholinergic , morris water navigation task , nissl body , pharmacology , endocrinology , hippocampus , pathology , inflammation , cognition , staining , alternative medicine , psychiatry , acupuncture
Postoperative cognitive dysfunction (POCD) after anesthesia and surgery (AS) is a common complication in the elderly population. A cholinergic-dependent signal, the alpha7-nicotinic acetylcholine receptor (α7-nAChR), has been suggested to regulate cognitive processes in a variety of neurologic diseases. In the current study, we determined whether electroacupuncture (EA) pretreatment ameliorates AS-induced POCD in aged rats, as well as the underlying mechanism.