Open AccessReduced Synaptic Plasticity Contributes to Resistance Against Constant-Stimulus Electroconvulsive Treatment in a Rat Model of Stress-Induced Depression
Author(s) -
Bin Wu,
Yuanyuan Guo,
Jie Deng,
Qibin Chen,
Su Min
Publication year - 2021
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s304075
Subject(s) - electroconvulsive therapy , long term potentiation , anhedonia , excitatory postsynaptic potential , medicine , synaptic plasticity , hippocampal formation , morris water navigation task , neuroscience , treatment resistant depression , hippocampus , antidepressant , endocrinology , anesthesia , electroconvulsive shock , psychology , inhibitory postsynaptic potential , receptor , dopamine
Depression is a common mood disorder in humans worldwide. Electroconvulsive therapy (ECT) remains the most effective treatment for patients with drug-resistant or severe depression; however, during ECT, electrical resistance can occur, antagonizing ECT efficacy. We aimed to investigate how depressed patients develop resistance to electric shocks during ECT.