Open Access<p>Transcription Factor E2F1 Aggravates Neurological Injury in Ischemic Stroke via microRNA-122-Targeted Sprouty2</p>
Author(s) -
Yi Wu,
Zhiqiang Gao,
Jiang Zhang
Publication year - 2020
Publication title -
neuropsychiatric disease and treatment
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s271320
Subject(s) - e2f1 , apoptosis , medicine , microrna , autophagy , cell cycle , cancer research , viability assay , transcription factor , mapk/erk pathway , microbiology and biotechnology , biology , signal transduction , cancer , biochemistry , gene
It has been documented that microRNAs (miRs) assume a pivotal role in the development of ischemic stroke (IS). However, it remains poorly identified about the role of miR-122 in IS. Herein, this study was intended to explore the mechanism of E2F1-orchestrated miR-122 in IS.