Open Access<p>Conditioned taste aversion memory extinction temporally induces insular cortical BDNF release and inhibits neuronal apoptosis</p>
Author(s) -
Dianwei Liu,
Ling Ma,
Xuhua Zhang,
Yunyan Wang
Publication year - 2019
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s215289
Subject(s) - tropomyosin receptor kinase b , neurotrophic factors , extinction (optical mineralogy) , mapk/erk pathway , brain derived neurotrophic factor , taste aversion , medicine , endocrinology , kinase , neuroscience , receptor , biology , microbiology and biotechnology , taste , paleontology
Memory extinction has been reported to be related to psychiatric disorders, such as post-traumatic stress disorder (PTSD). Secretion and synthesis of brain-derived neurotrophic factor (BDNF) have been shown to temporally regulate various memory processes via activation of tropomyosin-related kinase B (TrkB) receptors. However, whether memory extinction induces the synthesis and secretion of BDNF on the basis of its localization is not understood. In this study, we aim to investigate activity-dependent BDNF secretion and synthesis in the insular cortex (IC) in the setting of conditioned taste aversion (CTA) memory extinction.