Open Access<p>A single-nucleotide polymorphism influences brain morphology in drug-naïve patients with major depressive disorder</p>
Author(s) -
Asuka Katsuki,
Shingo Kakeda,
Keita Watanabe,
Ryohei Igata,
Yuka Otsuka,
Taro Kishi,
Le Hoa Nguyen,
Issei Ueda,
Nakao Iwata,
Yukunori Korogi,
Reiji Yoshimura
Publication year - 2019
Publication title -
neuropsychiatric disease and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 67
eISSN - 1178-2021
pISSN - 1176-6328
DOI - 10.2147/ndt.s204461
Subject(s) - single nucleotide polymorphism , major depressive disorder , medicine , snp , genotype , orbitofrontal cortex , magnetic resonance imaging , bioinformatics , oncology , genetics , gene , psychiatry , biology , radiology , cognition , amygdala , prefrontal cortex
Recently, a genome-wide association study successfully identified genetic variants associated with major depressive disorder (MDD). The study identified 17 independent single-nucleotide polymorphisms (SNPs) significantly associated with diagnosis of MDD. These SNPs were predicted to be enriched in genes that are expressed in the central nervous system and function in transcriptional regulation associated with neurodevelopment. The study aimed to investigate associations between 17 SNPs and brain morphometry using magnetic resonance imaging (MRI) in drug-naïve patients with MDD and healthy controls (HCs).