Open AccessEffects of Titanium Implant Surface Topology on Bone Cell Attachment and Proliferation in vitro
Author(s) -
Michael Levin,
Robert C. Spiro,
Himanshu Jain,
Matthias M. Falk
Publication year - 2022
Publication title -
medical devices
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.482
H-Index - 30
ISSN - 1179-1470
DOI - 10.2147/mder.s360297
Subject(s) - titanium , in vitro , materials science , implant , microbiology and biotechnology , chemistry , topology (electrical circuits) , medicine , biology , mathematics , metallurgy , biochemistry , surgery , combinatorics
Titanium is commonly used for implants because of its corrosion resistance and osseointegration capability. It is well known that surface topology affects the response of bone tissue towards implants. In vivo studies have shown that in weeks or months, bone tissue bonds more efficiently to titanium implants with rough surfaces compared to smooth surfaces. In addition, stimulating early endosseous integration increases the long-term stability of bone-implants and hence their clinical outcome. Here, we evaluated the response of human MG-63 osteoblast-like cells to flat and solid, compared to rough and porous surface topologies in vitro 1-6 days post seeding. We compared the morphology, proliferation, and attachment of cells onto three smooth surfaces: tissue culture (TC) plastic or microscope cover glasses, machined polyether-ether-ketone (PEEK), and machined solid titanium, to cells on a highly porous (average R a 22.94 μm) plasma-sprayed titanium surface (composite Ti-PEEK spine implants).