Open AccessDifferences and Similarities in Spontaneous Activity Between Animal Models of Cancer-Induced Pain and Neuropathic Pain
Author(s) -
Yong Fang Zhu,
Peter Kan,
Gurmit Singh
Publication year - 2022
Publication title -
journal of pain research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 49
ISSN - 1178-7090
DOI - 10.2147/jpr.s383373
Subject(s) - medicine , dorsal root ganglion , sensory system , neuropathic pain , hyperalgesia , sciatic nerve , electrophysiology , allodynia , nociception , anesthesia , neuroscience , anatomy , dorsum , receptor , biology
Clinical data on cancer-induced pain (CIP) demonstrate widespread changes in sensory function. It is characterized in humans not only by stimulus-invoked pain, but also by spontaneous pain. In our previous studies in an animal model of CIP, we observed changes in intrinsic membrane properties and excitability of dorsal root ganglion (DRG) sensory neurons corresponding to mechanical allodynia and hyperalgesia, of which abnormal activities of Aβ-fiber sensory neurons are consistent in a rat model of peripheral neuropathic pain (NEP).