Synthesis, In Silico and Pharmacological Evaluation of New Thiazolidine-4-Carboxylic Acid Derivatives Against Ethanol-Induced Neurodegeneration and Memory Impairment | Zendy

Shagufta Naz | Zendy; Lina T. Al Kury | Zendy; Humaira Nadeem | Zendy; Fawad Ali Shah | Zendy; Aman Ullah | Zendy; Rehan Zafar Paracha | Zendy; Muhammad Imran | Zendy; Shupeng Li | Zendy

Open Access

Synthesis, In Silico and Pharmacological Evaluation of New Thiazolidine-4-Carboxylic Acid Derivatives Against Ethanol-Induced Neurodegeneration and Memory Impairment

Author(s) -

Shagufta Naz,

Lina T. Al Kury,

Humaira Nadeem,

Fawad Ali Shah,

Aman Ullah,

Rehan Zafar Paracha,

Muhammad Imran,

Shupeng Li

Publication year - 2022

Publication title -

journal of inflammation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.656

H-Index - 33

ISSN - 1178-7031

DOI - 10.2147/jir.s357082

Subject(s) - neuroinflammation , neurodegeneration , neuroprotection , oxidative stress , pharmacology , chemistry , biochemistry , reactive oxygen species , inflammation , medicine , immunology , disease

Several studies revealed that alcohol utilization impairs memory in adults; however, the underlying mechanism is still unclear. The production of inflammatory markers and reactive oxygen species (ROS) plays a major role in neurodegeneration, which leads to memory impairment. Therefore, targeting neuroinflammation and oxidative distress could be a useful strategy for abrogating the hallmarks of ethanol-induced neurodegeneration. Moreover, several studies have demonstrated multiple biological activities of thiazolidine derivatives including neuroprotection.

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