Open AccessSynthesis, In Silico and Pharmacological Evaluation of New Thiazolidine-4-Carboxylic Acid Derivatives Against Ethanol-Induced Neurodegeneration and Memory Impairment
Author(s) -
Shagufta Naz,
Lina T. Al Kury,
Humaira Nadeem,
Fawad Ali Shah,
Aman Ullah,
Rehan Zafar Paracha,
Muhammad Imran,
Shupeng Li
Publication year - 2022
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s357082
Subject(s) - neuroinflammation , neurodegeneration , neuroprotection , oxidative stress , pharmacology , chemistry , biochemistry , reactive oxygen species , inflammation , medicine , immunology , disease
Several studies revealed that alcohol utilization impairs memory in adults; however, the underlying mechanism is still unclear. The production of inflammatory markers and reactive oxygen species (ROS) plays a major role in neurodegeneration, which leads to memory impairment. Therefore, targeting neuroinflammation and oxidative distress could be a useful strategy for abrogating the hallmarks of ethanol-induced neurodegeneration. Moreover, several studies have demonstrated multiple biological activities of thiazolidine derivatives including neuroprotection.