Open Access1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages
Author(s) -
Ao Duan,
Zhenqiang Ma,
Liu W,
Kai Shen,
Hao Zhou,
Shuai Wang,
Renyi Kong,
Yehong Shao,
Y Chen,
Guo W,
Liu F
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s339670
Subject(s) - calcitriol receptor , proinflammatory cytokine , extracellular matrix , chemistry , western blot , cartilage , receptor , inflammation , osteoarthritis , interleukin , chondrocyte , microbiology and biotechnology , endocrinology , medicine , cytokine , biology , pathology , biochemistry , alternative medicine , anatomy , gene , in vitro
Osteoarthritis (OA) is the most prevalent chronic joint disease globally. Loss of extracellular matrix (ECM) by chondrocytes is a classic feature of OA. Inflammatory cytokines, such as interleukin-1β (IL-1β) and interleukin-18 (IL-18), secreted mainly by macrophages, promote expression of matrix degrading proteins and further aggravate progression of OA. 1,25-dihydroxyvitamin D (1,25VD) modulates inflammation thus exerting protective effects on cartilage tissue. However, the underlying mechanisms of 1,25VD activity have not been fully elucidated.