Open AccessCould Mesna and Celery Seed Cotherapy Modulate Oxidative Stress and Inflammation of the Urinary Bladder Induced by Ifosfamide in Rabbits?
Author(s) -
Ayman Mousa,
Khaled S. Allemailem,
Fahad A. Alhumaydhi,
Faris Alrumaihi,
Ahmad Almatroudi,
Ameen S. S. Alwashmi,
Mohammad Abdullah Aljasir,
Osamah Al Rugaie,
Abdullah S. M. Aljohani,
Khaled E.A. Soliman,
Mohamad Yosof Rezk,
Ahmed Medhat Hegazy,
Hanan S. Seleem
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s337405
Subject(s) - mesna , hemorrhagic cystitis , oxidative stress , pharmacology , ifosfamide , acrolein , medicine , inflammation , urinary bladder , tbars , urinary system , chemistry , lipid peroxidation , immunology , cyclophosphamide , biochemistry , chemotherapy , etoposide , catalysis
Ifosfamide (IFS) has potential complications such as nephropathy and hemorrhagic cystitis (HC). Although mesna can prevent IFS-induced cystitis by direct binding and neutralization of acrolein, HC symptoms have still been observed clinically in most of these cases. Celery is a powerful healing vegetable that has antioxidant, anti-inflammatory, and anticancer effects. The current study evaluated the synergistic effects of mesna and celery seed on IFS-induced HC in rabbits.