Open AccessGinsenoside Rg1 Inhibits Microglia Pyroptosis Induced by Lipopolysaccharide Through Regulating STAT3 Signaling
Author(s) -
Yueyi Yao,
ChangYan Li,
Fang Qian,
Yu Zhao,
Xiaoyi Shi,
Daojun Hong,
Qinglong Ai,
Lianmei Zhong
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s326888
Subject(s) - pyroptosis , microglia , neuroinflammation , inflammasome , stat3 , microbiology and biotechnology , stat protein , chemistry , caspase 1 , lipopolysaccharide , aim2 , inflammation , biology , signal transduction , immunology
Neuroinflammation runs through the whole process of nervous system diseases and brain injury. Inflammasomes are thought to be especially relevant to immune homeostasis, and their dysregulation contributes to pyroptosis. The natural compound Ginsenoside Rg1 has been shown to possess anti-inflammatory effects; however, its underlying mechanisms are not entirely clear. Therefore, this study was undertaken to investigate the role and mechanisms of Rg1 in regulating the production of inflammasomes and pyroptosis of microglia in vivo and in vitro.