Open AccessMelatonin Inhibits Migration and Invasion in LPS-Stimulated and -Unstimulated Prostate Cancer Cells Through Blocking Multiple EMT-Relative Pathways
Author(s) -
Qi-Xing Tian,
Zhihui Zhang,
Qinglin Ye,
Shen Xu,
Hong Qian,
Wei-Yang Xing,
Lei Chen,
Dexin Yu,
Xu D,
Dongdong Xie
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s305450
Subject(s) - melatonin , lncap , protein kinase b , signal transduction , du145 , chemistry , phosphorylation , microbiology and biotechnology , cell migration , epithelial–mesenchymal transition , tlr4 , cancer cell , biology , downregulation and upregulation , endocrinology , cell , biochemistry , cancer , genetics , gene
Gram-negative bacteria are usually found in prostate cancer (PCa) tissues. This study aims to investigate the role of lipopolysaccharide (LPS), a glycolipid compound found in the outer membrane of gram-negative bacteria, on the migration and invasion of PCa cells, and to evaluate the protective effect of melatonin.