Open AccessSIRT1 is Required for Exercise-Induced Beneficial Effects on Myocardial Ischemia/Reperfusion Injury
Author(s) -
Dawei Wang,
Hongyan Cao,
Xu Wang,
Wang Jin-chun,
Manli Wang,
Jiän Zhang,
Lin Wang
Publication year - 2021
Publication title -
journal of inflammation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.656
H-Index - 33
ISSN - 1178-7031
DOI - 10.2147/jir.s300997
Subject(s) - tunel assay , oxidative stress , cardioprotection , blot , apoptosis , medicine , reperfusion injury , ischemia , endocrinology , pharmacology , immunohistochemistry , chemistry , biochemistry , gene
Exercise training has been regarded as an effective mean of prevention and treatment of cardiovascular diseases (CVD), and exercise can improve the antioxidant capacity of the myocardial. While SIRT1 has been proved to protects the heart from myocardial ischemia/reperfusion (MI/R) injury and apoptosis, less is known about the association between exercise-induced cardioprotection and SIRT1.