Open Access<p>Evaluation of in vitro Penetration of Fluticasone Propionate from MP-AzeFlu and Fluticasone Propionate Nasal Spray Through EpiAirway™606 Tissues Using Vertical Diffusion Cells</p>
Author(s) -
William Berger,
Claus Bachert,
Robert Allara,
Arkady Koltun,
Ferdinand Kopietz,
Joachim Maus,
Alexander D D'Addio
Publication year - 2020
Publication title -
journal of asthma and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.162
H-Index - 30
ISSN - 1178-6965
DOI - 10.2147/jaa.s238421
Subject(s) - fluticasone propionate , nasal spray , medicine , penetration (warfare) , nasal administration , bioavailability , in vitro , chromatography , pharmacology , inhalation , anesthesia , chemistry , biochemistry , operations research , engineering
Most patients with allergic rhinitis (AR) have moderate-to-severe disease, requiring complete and prompt relief when symptoms occur. The time course of fluticasone propionate (FP) penetration into nasal tissues after intranasal administration is not well characterized. The goal of this proof-of-concept study was to evaluate the mucosal penetration of FP from fixed-combination FP-azelastine nasal spray (MP-AzeFlu) compared with an FP-only nasal spray in an in vitro, 3-dimensional human bronchial tissue model.