Open Access<p>New-Onset Uveitis Possibly Caused by Secukinumab in a 47-Year-Old Male Patient with Long-Standing Ankylosing Spondylitis</p>
Author(s) -
Huda Nadwi,
Murad Janaini,
Mohammed Zammo,
Mohamed Cheikh,
Hani Almoallim
Publication year - 2020
Publication title -
international medical case reports journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.198
H-Index - 11
ISSN - 1179-142X
DOI - 10.2147/imcrj.s265812
Subject(s) - secukinumab , medicine , ankylosing spondylitis , uveitis , adalimumab , etanercept , spondylitis , hla b27 , dermatology , ophthalmology , surgery , disease , immunology , rheumatoid arthritis , human leukocyte antigen , psoriasis , psoriatic arthritis , antigen
Secukinumab, "an IL-17 antagonist", is one of the biological agents used to treat active ankylosing spondylitis (AS). Although it has been proven that certain agents are linked with a paradoxical increase in uveitis, there are limited data on whether secukinumab has this effect or not. We report a case of a new-onset anterior uveitis after 6 months of starting secukinumab in a 47-year-old male, HLA-B27 positive AS patient. He had a long-standing history with the disease over 25 years. He was treated in the past with methotrexate then adalimumab and later on with etanercept. He had no history of uveitis during all of this time. The uveitis was mild and treated conventionally with local measures while secukinumab was maintained. After a close follow-up, the uveitis had completely resolved. Is this part of the original disease or a possible side effect from secukinumab?