Open AccessGold Nanoparticles Dissolve Extracellularly in the Presence of Human Macrophages
Author(s) -
Sarah McCarrick,
Klara Midander,
Magdaléna Krausová,
Ulrika Carlander,
Hanna Karlsson
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s314643
Subject(s) - dissolution , colloidal gold , biophysics , macrophage , extracellular , nanotoxicology , intracellular , chemistry , mononuclear phagocyte system , peroxynitrite , in vitro , nanoparticle , materials science , nanotechnology , biochemistry , superoxide , immunology , biology , enzyme
Gold nanoparticles (AuNPs) have the potential to be used in various biomedical applications, partly due to the inertness and stability of gold. Upon intravenous injection, the NPs interact with the mononuclear phagocyte system, first with monocytes in the blood and then with macrophages in tissue. The NP-macrophage interaction will likely affect the stability of the AuNPs, but this is seldom analyzed. This study aimed to elucidate the role of macrophages in the biodissolution of AuNPs and underlying mechanisms.