Open AccessTargeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Author(s) -
Xianghong Peng,
Ximei Qian,
Hui Mao,
Andrew Y. Wang,
Zhuo Georgia Chen,
Shuming Nie,
Dong M. Shin
Publication year - 2008
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s2824
Subject(s) - magnetic resonance imaging , iron oxide nanoparticles , in vivo , nanoparticle , materials science , nanotechnology , molecular imaging , monoclonal antibody , magnetic nanoparticles , nanomaterials , preclinical imaging , nanomedicine , medicine , antibody , immunology , radiology , microbiology and biotechnology , biology
Magnetic iron oxide (IO) nanoparticles with a long blood retention time, biodegradability and low toxicity have emerged as one of the primary nanomaterials for biomedical applications in vitro and in vivo. IO nanoparticles have a large surface area and can be engineered to provide a large number of functional groups for cross-linking to tumor-targeting ligands such as monoclonal antibodies, peptides, or small molecules for diagnostic imaging or delivery of therapeutic agents. IO nanoparticles possess unique paramagnetic properties, which generate significant susceptibility effects resulting in strong T2 and T*2 contrast, as well as T1 effects at very low concentrations for magnetic resonance imaging (MRI), which is widely used for clinical oncology imaging. We review recent advances in the development of targeted IO nanoparticles for tumor imaging and therapy.