Open AccessTumour-Targeted and Redox-Responsive Mesoporous Silica Nanoparticles for Controlled Release of Doxorubicin and an siRNA Against Metastatic Breast Cancer
Author(s) -
Sian Liu,
Siqi Chen,
Ye Hu,
Fan Yang,
Qin Huo,
Ni Xie
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s278724
Subject(s) - metastatic breast cancer , doxorubicin , breast cancer , cancer research , in vivo , cancer cell , cancer , biodistribution , drug delivery , mesoporous silica , metastasis , nanogel , pharmacology , chemistry , medicine , in vitro , chemotherapy , materials science , biology , nanotechnology , mesoporous material , biochemistry , microbiology and biotechnology , catalysis
Metastatic breast cancer seriously harms women's health and is currently the tumour type with the highest mortality rate in women. Recently, the combinatorial therapeutic approaches that integrate anti-cancer drugs and genetic agents is an attractive and promising strategy for the treatment of metastatic breast cancer. Moreover, such a combination strategy requires better drug carriers that can effectively deliver the cargo to the breast cancer cells and achieve controlled release in the cells to achieve better therapeutic effects.